New classes of self-cleaving ribozymes revealed by comparative genomics analysis
Identifieur interne : 000086 ( Main/Exploration ); précédent : 000085; suivant : 000087New classes of self-cleaving ribozymes revealed by comparative genomics analysis
Auteurs : Zasha Weinberg [États-Unis] ; Peter B. Kim [États-Unis] ; Tony H. Chen [États-Unis] ; Sanshu Li [États-Unis] ; Kimberly A. Harris [États-Unis] ; Christina E. Lünse [États-Unis] ; Ronald R. Breaker [États-Unis]Source :
- Nature chemical biology [ 1552-4450 ] ; 2015.
Abstract
Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA processing. However, such natural ribozymes are exceedingly rare, as evident by the fact that the discovery rate for new classes has dropped to one per decade from about one per year during the 1980s. Indeed, only 11 distinct ribozyme classes have been experimentally validated to date. Recently, we recognized that self-cleaving ribozymes frequently associate with certain types of genes from bacteria. Herein this synteny was exploited to identify divergent architectures for two previously known ribozyme classes and to discover additional noncoding RNA motifs that are self-cleaving RNA candidates. Three new self-cleaving classes, named twister sister, pistol and hatchet, have been identified from this collection, suggesting that even more ribozymes remain hidden in modern cells.
Url:
DOI: 10.1038/nchembio.1846
PubMed: 26167874
PubMed Central: 4509812
Affiliations:
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Kim</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Chen, Tony H" sort="Chen, Tony H" uniqKey="Chen T" first="Tony H." last="Chen">Tony H. 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Lünse</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Breaker, Ronald R" sort="Breaker, Ronald R" uniqKey="Breaker R" first="Ronald R." last="Breaker">Ronald R. Breaker</name><affiliation wicri:level="2"><nlm:aff id="A1">Howard Hughes Medical Institute, Yale University, Box 208103, New Haven, CT 06520-8103, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, Yale University, Box 208103, New Haven, CT 06520-8103</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular, Cellular and Developmental Biology, Yale University, Box 208103, New Haven, CT 06520-8103</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Molecular Biophysics and Biochemistry, Yale University, Box 208103, New Haven, CT 06520-8103, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Biophysics and Biochemistry, Yale University, Box 208103, New Haven, CT 06520-8103</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">Nature chemical biology</title><idno type="ISSN">1552-4450</idno><idno type="eISSN">1552-4469</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA processing. However, such natural ribozymes are exceedingly rare, as evident by the fact that the discovery rate for new classes has dropped to one per decade from about one per year during the 1980s. Indeed, only 11 distinct ribozyme classes have been experimentally validated to date. Recently, we recognized that self-cleaving ribozymes frequently associate with certain types of genes from bacteria. Herein this synteny was exploited to identify divergent architectures for two previously known ribozyme classes and to discover additional noncoding RNA motifs that are self-cleaving RNA candidates. Three new self-cleaving classes, named twister sister, pistol and hatchet, have been identified from this collection, suggesting that even more ribozymes remain hidden in modern cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Benner, Sa" uniqKey="Benner S">SA Benner</name></author><author><name sortKey="Ellington, Ad" uniqKey="Ellington A">AD Ellington</name></author><author><name sortKey="Tauer, A" uniqKey="Tauer A">A Tauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nissen, P" uniqKey="Nissen P">P Nissen</name></author><author><name sortKey="Hansen, J" uniqKey="Hansen J">J Hansen</name></author><author><name sortKey="Ban, N" uniqKey="Ban N">N Ban</name></author><author><name sortKey="Moore, Pb" uniqKey="Moore P">PB Moore</name></author><author><name sortKey="Steitz, Ta" uniqKey="Steitz T">TA Steitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Gilna</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardner, Pp" uniqKey="Gardner P">PP Gardner</name></author><author><name sortKey="Barquist, L" uniqKey="Barquist L">L Barquist</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Nawrocki, Ep" uniqKey="Nawrocki E">EP Nawrocki</name></author><author><name sortKey="Weinberg, Z" uniqKey="Weinberg Z">Z Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberg, Z" uniqKey="Weinberg Z">Z Weinberg</name></author><author><name sortKey="Breaker, Rr" uniqKey="Breaker R">RR Breaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruminski, Dj" uniqKey="Ruminski D">DJ Ruminski</name></author><author><name sortKey="Webb, Ch" uniqKey="Webb C">CH Webb</name></author><author><name sortKey="Riccitelli, Nj" uniqKey="Riccitelli N">NJ Riccitelli</name></author><author><name sortKey="Luptak, A" uniqKey="Luptak A">A Luptak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Weinberg, Zasha" sort="Weinberg, Zasha" uniqKey="Weinberg Z" first="Zasha" last="Weinberg">Zasha Weinberg</name></region><name sortKey="Breaker, Ronald R" sort="Breaker, Ronald R" uniqKey="Breaker R" first="Ronald R." last="Breaker">Ronald R. Breaker</name><name sortKey="Breaker, Ronald R" sort="Breaker, Ronald R" uniqKey="Breaker R" first="Ronald R." last="Breaker">Ronald R. Breaker</name><name sortKey="Breaker, Ronald R" sort="Breaker, Ronald R" uniqKey="Breaker R" first="Ronald R." last="Breaker">Ronald R. Breaker</name><name sortKey="Chen, Tony H" sort="Chen, Tony H" uniqKey="Chen T" first="Tony H." last="Chen">Tony H. Chen</name><name sortKey="Harris, Kimberly A" sort="Harris, Kimberly A" uniqKey="Harris K" first="Kimberly A." last="Harris">Kimberly A. Harris</name><name sortKey="Harris, Kimberly A" sort="Harris, Kimberly A" uniqKey="Harris K" first="Kimberly A." last="Harris">Kimberly A. Harris</name><name sortKey="Kim, Peter B" sort="Kim, Peter B" uniqKey="Kim P" first="Peter B." last="Kim">Peter B. Kim</name><name sortKey="Li, Sanshu" sort="Li, Sanshu" uniqKey="Li S" first="Sanshu" last="Li">Sanshu Li</name><name sortKey="Li, Sanshu" sort="Li, Sanshu" uniqKey="Li S" first="Sanshu" last="Li">Sanshu Li</name><name sortKey="Lunse, Christina E" sort="Lunse, Christina E" uniqKey="Lunse C" first="Christina E." last="Lünse">Christina E. Lünse</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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